Analisis Farmakokinetik Klinik Dosis Obat Pasien Hipertensi Komplikasi Gagal Di RSUD Dr. Pirngadi Medan
DOI:
https://doi.org/10.52622/jisk.v4i1.06Kata Kunci:
Hypertension, kidney failure, drug dose adjustment, clinical pharmacokineticsAbstrak
Background: Hospitals are health service providers providing emergency care, outpatient and inpatient. Hypertension occurs when blood pressure is above normal. Clinical conditions that require dialysis treatment have a tendency to kidney failure. This effort is related to the field of clinical pharmacokinetics. Objective: The study was conducted to analyze the dose of drug administration in conditions complicated by kidney failure in hypertensive patients. Methods: The study went through a sampling stage of data from hypertensive patients complicated by kidney failure, data according to inclusion criteria, calculation of creatinine clearance, analysis of dose adjustments and creatinine clearance. Results: The study obtained 170 data, which met the inclusion criteria of 30 data. Drugs with a narrow therapeutic index and worsening kidney function that patients received included: digoxin, captopril, ranitidine, furosemide, ciprofloxacin, and cefriaxone in 2, 13, 9, 12, 3, and 8 cases respectively. Conclusion: According to dose adjustment calculations for patient creatinine clearance, it was found that the drug exceeded the individual dose in 6 out of 9; 8 of 13; and 2 cases each using ranitidine, captopril, digoxin
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Peraturan Pemerintah, Peraturan Pemerintah RI No. 47 Thn 2021 tentang Penyelengaraan Bidang Perumahsakitan. Jakarta: Kementerian Sekretaris Negara RI, 2021.
E. Triyanto, Pelayanan Keperawatan bagi Penderita Hipertensi secara Terpadu. Yogyakarta: Graha Ilmu, 2014.
A. A. A. E. Cahyani, D. Prasetya, M. F. Abadi, and D. Prihatiningsih, “Gambaran Diagnosis Pasien Pra-Hemodialisa di RSUD Wangaya Tahun 2020-2021,” J. Ilm. Hosp., vol. 11, no. 1, pp. 661–666, 2022.
A. Setyaningsih, D. Puspita, and M. I. Rosyidi, “Perbedaan Kadar Ureum & Creatinin pada Klien yang Menjalani Hemodialisa dengan Hollow Fiber Baru dan Hollow Fiber Re ZUse di RSUD Ungaran,” J. Keperawatan Med. Bedah, vol. 1, no. 1, pp. 15–24, 2013.
D. Widayati and N. Lestari, “Peningkatan Kualitas Hidup pada Penderita Gagal Ginjal Kronik yang Menjalani Terapi Hemodialisa melalui Psychological Intervention di Unit Hemodialisa RSUD Gambiran Kediri,” J. ilmu Kesehat., vol. 3, no. 2, pp. 6–11, 2017.
M. Weldegiorgis and M. Woodward, “The Impact of Hypertension on Chronic Kidney Disease and End-Stage Renal Disease is Greater in Men than Women: A Systematic Review and Meta-Analysis,” BMC Nephrol., vol. 21, pp. 1–9, 2020.
S. M. Hamrahian and B. Falkner, “Hypertension in Chronic Kidney Disease,” Hypertens. from basic Res. to Clin. Pract., pp. 307–325, 2017.
S. Mennuni, S. Rubattu, G. Pirelli, G. Tocci, C. Fofi, and M. Volpe, “Hypertension and Kidneys: Unraveling Complex Molecular Mechanisms Underlying Hypertensive Renal Damage,” J. Hum. Hypertens., vol. 28, no. 2, pp. 74–79, 2014.
H. C. Ansel, Pengantar Bentuk Sediaan Farmasi, Edisi IV. Jakarta: Universitas Indonesia, 1989.
L. Shargel, B. C. Andrew, and S. Wu-Pong, Applied Biopharmaceutics & Pharmacokinetics. Stamford: Appleton & Lange, 1999.
L. A. Bauer, Clinical Pharmacokinetics and book. Washington: McGraw Hill., 2006.
C. Martindale and S. C. Sweetman, The complete drug reference. London: Pharmaceutical Press, 2009.
E. Iisalo, “Clinical Pharmacokinetics of Digoxin,” Clin. Pharmacokinet., vol. 2, no. 1, pp. 1–16, 1977.
O. H. Drummer, B. S. Workman, P. J. Miach, B. Jarrott, and W. J. Louis, “The Pharmacokinetics of Captopril and Captopril Disulfide Conjugates in Uraemic Patients on Maintenance Dialysis: Comparison with Patients with Normal Renal Function,” Eur. J. Clin. Pharmacol., vol. 32, pp. 267–271, 1987.
D. Czock and F. M. Rasche, “Dose Adjustment of Ciprofloxacin in Renal Failure: Reduce The Dose or Prolong The Administration Interval,” Eur J Med Res, vol. 10, no. 4, pp. 145–148, 2005.
I. H. Patel, J. G. Sugihara, R. E. Weinfeld, E. G. Wong, A. W. Siemsen, and S. J. Berman, “Ceftriaxone Pharmacokinetics in Patients with Various Degrees of Renal Impairment,” Antimicrob. Agents Chemother., vol. 25, no. 4, pp. 438–442, 1984.
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