Direct Compression Tablets Bay Leaf Ethanol Extract (Syzygium Polyanthum)

Authors

  • Muhammad Gunawan Program Studi Farmasi, STIKes Indah Medan Author
  • Suprianto Program Studi Farmasi, STIKes Indah Medan Author
  • Samran Program Studi Farmasi, STIKes Indah Medan Author
  • Cut Fatimah Program Studi Farmasi, STIKes Indah Medan Author
  • Debi Melani Program Studi Farmasi, STIKes Indah Medan Author
  • Sumardi Universitas Tjut Nyak Dhien Author

DOI:

https://doi.org/10.52622/jisk.v2i3.31

Keywords:

Salam leaf, extract, tablet, direct compression, lactose, avicel

Abstract

Indonesia's natural wealth that is efficacious in suppressing cholesterol, hypertension, diarrhea, gastritis and blood sugar is one of the bay leaves (Syzygium polyanthum Wight.). Tablets are preparations that are practical to use, easy to produce, pack, and distribute. The research was directed to make tablets of bay leaf ethanol extract (EEDS) by direct compression. EEDS tablets were made into four formulas with various fillers of lactose and Avicel PH 102, each 200 mg : 135 mg A); 250 mg : 105 mg (B); 300 mg : 55 mg (C); and 350 mg : 5 mg (D). The study showed that all formulas met the preformulation test requirements and tablet evaluation, D as the best formula. EEDS is made into tablets by direct compression.

Downloads

Download data is not yet available.

References

Silalahi M. Syzygium polyanthum (Wight) Walp. J Din Pendidik. 2017;10(1):1–16.

https://doi.org/10.51212/jdp.v10i1.408

Dewi IL. Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Salam (Eugenia polyantha) terhadap Tikus Galur Wistar yang Diinduksi Aloksan. Universitas Muhammadiyah Surakarta; 2013.

Rival H, Yulianti S, Chandra B. Qualitative and Quantitative Analysis of Hexane, Acetone Ethanol and Water Extract from Bay Leaves (Syzgium polyanthum (Wight) Walp.). Pharm Chem J. 2019;6(3):13–20.

Prihapsara F, Artanti AN, Harini M, Widiyani T, Nazilla SZ, Widoninggar R. Anti-Diabetic Activity of Self-Microemulsifying Drug Delivery Systems from Bay Leaves (Eugenia polyantha Wight) with Virgin Coconut Oil as A Carrier. Iran J Pharm Sci. 2020;16(2):45–56. https://dx.doi.org/10.22034/ijps.2019.99328.1508

Wijayakusuma H. Tumbuhan Berkhasiat Obat Indonesia Rempah, Rimpang dan Umbi. Jakarta: Prestasi Instan Indonesia; 2002.

Studiawan H, Santosa MH. Uji Aktivitas Penurun Kadar Glukosa Darah Ekstrak Daun Eugenia polyantha pada Mencit yang Diinduksi Aloksan. Media Kedokt Hewan. 2005;21(2):62–5.

Permata PN, Kartadarma E, Gadri A. Pengaruh Pengikat Pvp dan Amylum Manihot serta Perbedaan Metode Ekstraksi terhadap Karakteristik Sediaan Tablet Mengandung Ekstrak Daun Kersen (Muntingia Calabura L.). Pros Farm. 2015;1(2):147–53. http://dx.doi.org/10.29313/.v0i0.1652

El-Bagory I, Barakat N, Ibrahim MA, El-Enazi F. Formulation and In Vitro Evaluation of Theophylline Matrix Tablets Prepared by Direct Compression: Effect of Polymer Blends. Saudi Pharm J. 2012;20(3):229–38. https://doi.org/10.1016/j.jsps.2011.11.007

Augsburger LL, Hoag SW. Pharmaceutical Dosage Form Tablets. New York: CRC press; 2016.

Departemen Kesehatan Republik Indonesia. Farmakope Indonesia. Edisi Tiga. Jakarta: Departemen Kesehatan Republik Indonesia; 1979.

Stevani H. Praktikum Farmakologi. Jakarta: Kemenkes RI; 2016.

Vilegave K, Vidyasagar G, Chandankar P. Preformulation Studies of Pharmaceutical New Drug Molecule and Products: An Overview. Am J Pharm Heal Res. 2013;1(3):1–20.

Bharate SS, Vishwakarma RA. Impact of Preformulation on Drug Development. Expert Opin Drug Deliv. 2013;10(9):1239–57. https://doi.org/10.1517/17425247.2013.783563

Hoag SW. Pharmaceutical Dosage Forms Tablets. New York: CRC Press; 2016.

Gaisford S, Saunders M. Essentials of Pharmaceutical Preformulation. London: John Wiley & Sons; 2012.

Parikh DM. Handbook of Pharmaceutical Granulation Technology. New York: CRC Press; 2016.

Qureshi SA. Tablet Testing. In: Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition. Fourth Edi. CRC Press; 2013. p. 3569–81. https://doi.org/10.1081/E-EPT4

Departemen Kesehatan Republik Indonesia. Farmakope Indonesia. Ed. Empat. Jakarta: Departemen Kesehatan Republik Indonesia; 1995.

Departemen Kesehatan Republik Indonesia. Materia medika Indonesia. Jilid Lima. Jakarta: Departemen Kesehatan Republik Indonesia; 1989.

Downloads

Published

31-12-2021

How to Cite

[1]
Muhammad Gunawan, Suprianto, Samran, Cut Fatimah, Debi Melani, and Sumardi , Trans., “Direct Compression Tablets Bay Leaf Ethanol Extract (Syzygium Polyanthum)”, jisk, vol. 2, no. 3, pp. 1–6, Dec. 2021, doi: 10.52622/jisk.v2i3.31.

Similar Articles

1-10 of 35

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

1 2 3 4 > >>