Application of the Routine Level Determination Method for Paracetamol PT. Kimia Farma, Tbk HPLC on Generic and Branded Tablets in Medan

Authors

  • Suprianto Fakultas Farmasi, Institut Kesehatan Helvetia Medan Author
  • Darwin Syamsul Fakultas Farmasi, Institut Kesehatan Helvetia Medan Author
  • Muhammad Deddy Harfiansyah Fakultas Farmasi, Institut Kesehatan Helvetia Medan Author

DOI:

https://doi.org/10.52622/9abdjn64

Keywords:

Levels, pparacetamol, tablets, HPLC

Abstract

Paracetamol is a drug that is analgesic and antipyretic, which is produced as a generic or branded drug. The research objective was to determine the quality based on paracetamol levels in generic and branded tablet preparations circulating in Medan. The research used HPLC Alliance e2696 UV / Visible Detector 2489, Column µ Bondapak TMC-18: 10 µm 125A 3.9x300 mm, UV-Vis Spectrophotometer Agilent 8453. The method used was a routine assay method for paracetamol PT. Kimia Farma. The results showed that the paracetamol content in the tablet dosage was 97.05% - 106.04%, according to the Indonesian Pharmacopoeia Edition V, not less than 90% and not more than 110%.

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References

Ansel, Howard C. 1989. Pengantar Bentuk Sediaan Farmasi. Jakarta: Universitas Indonesia Press.

Cairns, Donald. 2004. Intisari Kimia Farmasi. Jakarta: Buku Kedokteran EGC.

Depkes R I. 1995. Farmakope Indonesia. Edisi IV. Jakarta: Depkes RI.

Gandjar, Ibnu Gholib, and Abdul Rohman. 2018. Spektroskopi Molekuler Untuk Analisis Farmasi.

Yogyakarta: UGM Press.

Gunawan, Sulistia Gan, R Setiabudy, and Elysabeth Nafrialdi. 2007. Farmakologi Dan Terapi. Edisi

V. Jakarta: Departemen Farmakologi dan Terapeutik FKUI.

Idris, F, and M Widjajarta. 2006. Obat Generik Harga Murah Tapi Mutu Tidak Kalah. Jakarta: PB IDI.

Kemenkes RI. 2014. Farmakope Indonesia. Edisi V. Jakarta: Ditjen. Bina Kefarmasian dan Alat

Kesehatan Republik Indonesia.

MenKes RI. 2010. Peraturan Menteri Kesehatan Nomor: HK.02.02/Menkes/068/I/2010 Tentang

Kewajiban Menggunakan Obat Generik di Fasilitas Pelayanan Kesehatan Pemerintah. Jakarta:

Departemen Kesehatan Republik Indonesia.

Naldi, Eki. 2010. “Penetapan Kadar Campuran Ibuprofen dan Parasetamol dalam Sediaan Tablet

secara Volumetri.” Skripsi, Universitas Sumatera Utara.

Santoso, Singgih. 2010. Statistik Non Parametrik. Jakarta: Elex Media Komputindo.

Suprianto. 2018. “Optimization of Mobile Phase for Simultaneous Determination of Sweeteners,

Preservatives and Dyes by UFLC.” International Journal of ChemTech Research 11 (1): 56–63. https://doi.org/10.5281/ZENODO.1246180.

Wibowo, Agus. 2009. Cerdas Memilih Obat dan Mengenali Penyakit. Jakarta: PT. Lingkar Pena

Kreativa.

Wibowo, Ari. 2017. “Uji Chi-Square Pada Statistika Dan SPSS.” Jurnal Ilmiah Sinus 4 (2): 37–46.

Yulyarti, Endhah, Yusnita Rifai, and Risfah Yulianty. 2018. “Penetapan Kadar Parasetamol, Kafein,

dan Propifenazon secara Simultan dalam Sedian Tablet dengan Metode KCKT.” Majalah

Farmasi dan Farmakologi 22 (1): 1–4. https://doi.org/10.20956/mff.v22i1.5687.

Yusuf, Faisal. 2016. “Studi Perbandingan Obat Generik dan Obat dengan Nama Dagang.” Jurnal

Farmanesia 3 (1): 5–10.

Zullies, Ikawati. 2010. Cerdas Mengenali Obat. Yogyakarta: Kanisiuss

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Published

— Updated on 31-12-2020

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Vol. 1 No. 1 (2020): Jurnal Indah Sains dan Klinis

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How to Cite

[1]
Suprianto, Darwin Syamsul, and Muhammad Deddy Harfiansyah , Trans., “Application of the Routine Level Determination Method for Paracetamol PT. Kimia Farma, Tbk HPLC on Generic and Branded Tablets in Medan”, jisk, vol. 1, no. 1, pp. 1–5, Dec. 2020, doi: 10.52622/9abdjn64.

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