Analysis of Dexamethasone Herbal Medicine for Aches and Pains in Lubuk Pakam using the Spectrophotometric Method

Authors

  • Cucu Arum Dwi Cahya Fakultas Farmasi, Institut Kesehatan Medistra Lubuk Pakam, Indonesia Author
  • Sri Rezeki Anggriani Fakultas Farmasi, Institut Kesehatan Medistra Lubuk Pakam, Indonesia Author

DOI:

https://doi.org/10.52622/jisk.v4i1.03

Keywords:

Dexamethasone, Rheumatic Pain Herbal Medicine,, UV-Vis Spectrophotometry

Abstract

Background: Chemical drugs are prohibited from being contained in traditional medicine doses. Based on BPOM findings in 2015-2017, almost 100 traditional herbal medicine products contain medicinal chemicals (BKO), including dexamethasone. Objective: Study to determine dexamethasone levels and the level of control in herbal medicine for rheumatic pain in the Lubuk Pakam area. Method: The UV-Fis spectrophotometric method was used for quantitative analysis. Meanwhile, for qualitative analysis, the reagents used were the addition of anhydrous acetic acid and concentrated sulfuric acid. Results: Analysis with the addition of this reagent showed that 5 samples contained dexamethasone. UV-Fis spectrophotometric analysis showed dexamethasone levels in samples A1 to A5 were 4.069; 4,229; 4,416; 11,788; and 5,270 mg/g. Conclusion: The research results showed that all five samples contained Dexamethasone at certain levels in the Lubuk Pakam area, North Sumatra

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References

M. R. Adiyasa and M. Meiyanti, “Pemanfaatan Obat Tradisional di Indonesia,” J. Biomedika Dan Kesehat., vol. 4, no. 3, pp. 130–138, 2021.

A. Wirastuti, A. A. Dahlia, and A. Najib, “Pemeriksaan Kandungan Bahan Kimia Obat (BKO) Prednison pada Beberapa Sediaan Jamu Rematik,” J. Fitofarmaka Indones., vol. 3, no. 1, pp. 130–134, 2016.

A. Roni and T. Minarsih, “Identifikasi Allopurinol dan Deksametason dalam Jamu secara Simultan dengan Metode Kromatografi Lapis Tipis (KLT),” Indones. J. Pharm. Nat. Prod., vol. 4, no. 2, 2021.

Badan Pengawas Obat dan Makanan Republik Indonesia, “Siaran Pers-Badan Pengawas Obat dan Makanan.” Badan Pengawas Obat dan Makanan Republik Indonesia, Jakarta, 2022.

S. Ganiswara, R. Setiabudi, and U. S. Z. B. F. dan Terapi, Farmakologi, Edisi IV. Jakarta: Bagian Farmakol Fak Kedokt Univ Indonesia., 2016.

R. Ayu, D. B. Pambudi, and Y. W. Permadi, “Gambaran Karakteristik Pemakaian Golongan Kortikosteroid pada Pasien Anak di Puskesmas Kesesi I Kabupaten Pekalongan,” in Prosiding University Research Colloquium, 2021, pp. 666–669.

E. Hidayati, I. K. Berata, Samsuri, I. M. Merdana, and L. M. Sudimartini, “Gambaran Histopatologi Limpa Tikus Putih yang Diberi Deksametason dan Vitamin E,” Bul. Vet. Udayana Vol., vol. 10, no. 1, pp. 18–25, 2018.

R. W. Foster, Basic Pharmacology. Elsevier, 2015.

M. A. Hernandez and A. Rathinavelu, Basic Pharmacology: Understanding Drug Actions and Reactions. Routledge, 2017.

R. S. Satoskar and S. D. Bhandarkar, Pharmacology and Pharmacotherapeutics. Elsevier India, 2020.

L. Sugiarti, R. P. Hutagaol, and T. Achyadi, “Analisis Senyawa Golongan Kortikosteroid Sintetik Deksametason dan Prednison) dalam Jamu secara Kromatografi Cair Kinerja Tinggi (KCKT),” J. Sains Nat., vol. 2, no. 1, pp. 1–11, 2012.

S. A. Saputra, “Identifikasi Bahan Kimia Obat dalam Jamu Pegel Linu Seduh dan Kemasan yang Dijual di Pasar Bandar,” J. Wiyata Penelit. Sains dan Kesehat., vol. 2, no. 2, pp. 188–192, 2017.

S. Suprianto, D. Syamsul, and M. D. Harfiansyah, “Application of the Routine Level Determination Method for Paracetamol PT. Kimia Farma, Tbk HPLC on Generic and Branded Tablets in Medan,” J. Indah Sains dan Klin., vol. 1, no. 1, p. 345728, 2020.

S. Suprianto, “Optimization of Mobile Phase for Simultaneous Determination of Sweeteners, Preservatives and Dyes by UFLC,” Int. J. ChemTech Res. 2018, vol. 11, no. 1, pp. 56–63, 2018.

H. Faisal, N. A. Pitri, S. Handayani, and D. S. Purnomo, “Analisa Vitamin C dan Evaluasi Sediaan Tablet Effervescent Campuran Ekstrak Etanol Biji Jambu Biji Merah dan Putih (Psidium guajava L.),” J. Indah Sains dan Klin., vol. 3, no. 1, pp. 1–7, 2022.

S. M. Fahira, A. D. Ananto, and W. Hajrin, “Analisis Kandungan Hidrokuinon dalam Krim Pemutih yang Beredar di Beberapa Pasar Kota Mataram dengan Spektrofotometri Ultraviolet-Visibel,” Spin J. Kim. Pendidik. Kim., vol. 3, no. 1, pp. 75–84, 2021.

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Published

30-04-2023

How to Cite

[1]
Cucu Arum Dwi Cahya and Sri Rezeki Anggriani , Trans., “Analysis of Dexamethasone Herbal Medicine for Aches and Pains in Lubuk Pakam using the Spectrophotometric Method”, jisk, vol. 4, no. 1, pp. 15–19, Apr. 2023, doi: 10.52622/jisk.v4i1.03.

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