Activity Test of Tamarind Seed Extract (Tamarindus indica) on Uric Acid in Male White Mice (Mus Musculus) Potassium Oxonate Induction

Authors

  • Asti Pratiwi Fakultas Farmasi, Institut Kesehatan Medistra Lubuk Pakam, Indonesia Author
  • Aminah Syarifuddin Fakultas Farmasi, Institut Kesehatan Medistra Lubuk Pakam, Indonesia Author
  • Cucu Arum Dwi Cahya Fakultas Farmasi, Institut Kesehatan Medistra Lubuk Pakam, Indonesia Author
  • Melinda Sari Fakultas Farmasi, Institut Kesehatan Medistra Lubuk Pakam, Indonesia Author

DOI:

https://doi.org/10.52622/jisk.v4i2.01

Keywords:

Seeds, Tamarind, decline, uric acid

Abstract

Background: The Tropical Tamarind Plant has great economic value and benefits for society, from the stems to the leaves it can be used to treat diseases, such as fever, dyspepsia and even gonorrhoea. The chemical components of Tamarind seeds include alkaloids, saponins, flavonoids, glycosides, malic acid, tartrate, pectin, arabinose, xylose, galactose and glucose. Objective: The study was directed to determine the activity of ethanol extract from tamarind seeds in reducing uric acid in mice. Methods: Preparation of dry extract of Tamarind seeds (EKBAJ), phytochemical screening, and testing the activity of reducing uric acid in mice induced by potassium oxonate at various concentrations of EKBAJ. Measure the levels with Easy Touch GCU. Results: EKBAJ can inhibit mouse uric acid synthesis. The higher the concentration of EKBAJ, the greater the effect on reducing uric acid levels. Conclusion: A concentration of 200 mg/kgBW had the greatest effect on reducing uric acid in mice.

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References

S. Cahyawati, W. Rumaolat, N. S. J. Rumi, and W. Rumaolat, “Factors Related to the Utilization of the Integrated Health Services Center for the Elderly,” J Ners, vol. 15, no. 2, pp. 63–66, 2020.

R. M. Rumanti, S. Suprianto, J. Tarigan, and A. M. S. Ramadani, “Combinant Potential Antibacterial Zingiber Officinale Var. Rubrum with Cinnamomum Burmannii Against Staphylococcus Aureus,” J. Indah Sains dan Klin., vol. 2, no. 1, pp. 6–10, 2021, doi: 10.52622/jisk.v2i1.8.

Nurhayati, “Hubungan Pola Makan dengan Terjadinya Penyakit Gout (Asam Urat) Di Desa Limran Kelurahan Pantoloan Boya Kecamatan Taweli,” J. Kesmas, vol. 7, no. 6, 2018.

S. O. Sativa and A. D. A. Kusuma, “Perbedaan Kadar Asam Urat Darah Sebelum dan Sesudah Pemberian Minuman Asam Jawa,” J. Penelit. Perawat Prof., vol. 2, no. 1, pp. 55–64, 2020.

V. Z. L. P. Ndede, W. Oroh, and H. Bidjuni, “Pengaruh Pemberian Rebusan Daun Salam terhadap Penurunan Kadar Asam Urat pada Penderita Gout Artritis Di Wilayah Kerja Puskesmas Ranotana Weru,” J. Keperawatan, vol. 7, no. 1, 2019.

L. Leny, I. Ginting, R. A. R. Hutabarat, S. Suprianto, and B. Iskandar, “Formulasi Krim Pelembab Kombinasi Ekstrak Lidah Buaya (Aloe vera) dan Ekstrak Kulit Manggis (Garcinia mangostana L.),” J. Islam. Pharm., vol. 7, no. 1, pp. 11–16, 2022.

M. A. Martsiningsih and D. Otnel, “Gambaran Kadar Asam Urat Darah Metode Basah (Uricase-PAP) pada Sampel Serum dan Plasma EDTA,” J. Teknol. Lab., vol. 5, no. 1, pp. 20–26, 2016.

I. N. Amalia, B. P. Pratama, I. J. Agustin, K. K. Khotimah, N. Lestari, and S. S. Jauza, “Pengaruh Pemberian Kompres Hangat Jahe Merah terhadap Tingkat Nyeri Arthritis Gout (Asam Urat),” Sehat Masada, vol. 15, no. 1, pp. 112–119, 2021.

M. Ginting, S. Suprianto, S. F. Hanum, D. Meilani, and M. Sartika, “Uji Ekstrak Kulit Buah Mangga Arum Manis dalam Etanol pada Tumbuh Kembang Escherichia coli dan Salmonella typhi,” J. Indah Sains dan Klin., vol. 3, no. 2, pp. 1–5, 2022.

F. K. D. H. D. Tua, “Pemberian Air Rebusan Daun Sirsak Terhadap Gout Arthritis Di Wilayah Kerja Puskesmas Deli Tua tahun 2020,” J. Penelit. Keperawatan Med., vol. 3, no. 1, pp. 73–81, 2020.

A. Faradiba, A. Gunadi, and D. Praharani, “Daya Antibakteri Infusa Daun Asam Jawa (Tamarindus indica Linn) terhadap Streptococcus mutans (Antibacterial Activity of Asam Jawa Leaf Infuse (Tamarindus indica Linn) against Streptococcus mutans,” Pustaka Kesehat., vol. 4, no. 1, pp. 55–60, 2016.

A. Mishra and M. Bajpai, “The Flocculation Performance of Tamarindus mucilage in Relation to Removal of Vat and Direct Dyes,” Bioresour. Technol., vol. 97, no. 8, pp. 1055–1059, 2006.

B. Harborne, Metode Fitokimia, Penuntun Cara Modern Menganalisis Tumbuhan. Bandung: Penerbit ITB, 1987.

V. R. Karlina and H. M. Nasution, “Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak Etanol Daun Jeruk Purut (Citrus hystrix DC) Terhadap Bakteri Staphylococcus Aureus dan Escherichia Coli,” J. Heal. Med. Sci., vol. 1, no. 2, pp. 131–139, 2022.

A. Yeti and R. Yuniarti, “Penetapan Kadar Flavonoid Total Ekstrak Etanol Herba Rumput Bambu (Lopatherum gracile Brongn.) Dengan Metode Spektrofotometri Visible,” J. Farm. Sains, dan Kesehat., vol. 1, no. 1, pp. 11–19, 2021.

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Published

31-08-2023

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Vol. 4 No. 2 (2023): Jurnal Indah Sains dan Klinis

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How to Cite

[1]
Asti Pratiwi, Aminah Syarifuddin, Cucu Arum Dwi Cahya, and Melinda Sari , Trans., “Activity Test of Tamarind Seed Extract (Tamarindus indica) on Uric Acid in Male White Mice (Mus Musculus) Potassium Oxonate Induction”, jisk, vol. 4, no. 2, pp. 1–8, Aug. 2023, doi: 10.52622/jisk.v4i2.01.

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