Preformulation of Lemongrass Oil (Cymbopogon citrates (DC) Stapf) and Turmeric Extract (Curcuma xanthorrhiza Roxb.) on the Growth of Escherichia coli Bacteria
DOI:
https://doi.org/10.52622/jisk.v4i2.05Kata Kunci:
Antibacterial, Escherichia coli, Cymbopogon citrates (DC) Stapf,, Curcuma xanthorrhiza RoxbAbstrak
Background: Lemongrass and turmeric are medicinal plants known for their antibacterial properties due to the presence of compounds such as alkaloids and flavonoids in lemongrass oil, and saponins and flavonoids in turmeric. Typically, lemongrass oil is used for massage oil, and turmeric is commonly used as a spice and traditional medicine. However, there is limited scientific information on the combination of both. Objective: This study aims to evaluate the antibacterial potential of a formulation combining lemongrass oil and turmeric extract against Escherichia coli bacteria, both in extract form. Method: The research steps include the preparation of the plant materials, extraction, granulation process, and antibacterial testing. Extraction is performed using boiling with distilled water as the solvent. The antibacterial activity testing method employed is the good diffusion method. Results: The formulation of lemongrass oil (Cymbopogon citratus (DC) Stapf) and turmeric (Curcuma xanthorrhiza Roxb.) has demonstrated antibacterial activity against Escherichia coli in both extract and granule forms across five different formulations. Conclusion: The highest inhibition diameter was observed with the combination of lemongrass oil and turmeric extract at 19.05 mm, and lemongrass oil and turmeric granules at 18.71 mm, in Formula 3 (0.25 lemongrass oil: 0.75 turmeric).
Unduhan
Referensi
D. RI, Inventaris Tanaman Obat Indonesia, Edisi Pertama. Jakarta: Departemen Kesehatan Republik Indonesia, 2000.
D. POM, Parameter Standar Umum Ekstrak Temulawak Obat, Cetakan Pertama. Jakarta: Departemen Kesehatan Republik Indonesia, 2000.
E. Dermawaty D, “Potential Extract Curcuma (Curcuma xanthorriza Roxb) As Antibacterial,” Majority, pp. 4, 5–11, 2015.
B. Akbar, Tumbuhan dengan Kandungan Senyawa Aktif yang Berpotensi Sebagai Bahan Infertilitas. Jakarta: Adabia Press, 2010.
D. Sudaryanti, “Memecah Dormansi Rimpang Temulawak (Curcuma xanthorrhiza Roxb) Menggunakan Larutan Atonik dan Stimulasi Perakaran dengan Aplikasi Auksin,” Jurnal Sains dan Teknologi Indonesia, vol. 12, no. 1, pp. 66–70, 2010.
M. A. Jamlili, M. N. Hidayat, and A. Hifizah, “Uji Daya Hambat Ramuan Herbal terhadap Pertumbuhan Staphylococcus aureus dan Salmonella thypi,” Jurnal IIP, vol. 1, no. 3, pp. 227–239, 2014.
L. Hadisoewignyo and A. Fudholi, Sediaan Solida. Yogyakarta: Pustaka Pelajar, 2013.
I. M. Famuyide, A. O. Aro, F. O. Fasina, and J. N. Eloff, “Antibacterial Activity and Mode of Action of Acetone Crude Leaf Extracts of Under Investigated Syzygium and Eugenia (Myrtaceae) Species on Multidrug Resistant Porcine Diarrhoeagenic Escherichia coli,” BMC Vet Res, vol. 15, no. 162, pp. 2–14, 2019.
B. G.S and A. N.R, Tablet. Editor. Lachman L. Teori dan Praktek Farmasi Industri, III., vol. II. Jakarta: UI Press, 1994.
R. A. Ambarwati, “Deteksi Adanya Pemalsuan Minyak Sereh dengan Menguji Putaran Optik Menggunakan Polarimeter Tipe ATAGO 2L,” Semarang: Universitas Diponegoro, 2011.
S. Bolton, Pharmaceutical Statistics Practical and Clinical Applications, Third. New York: Marcel Dekker. Ink., 1997.
M. Balouiri, M. Sadiki, and S. K. Ibnsouda, “Methods for In Vitro Evaluating Antimicrobial Activity A Review,” J Pharm Anal, vol. 6, no. 2, pp. 71–79, 2016.
R. Armando, Memproduksi Minyak Atsiri Berkualitas. Jakarta: Penebar Swadaya, 2009.
M. S. Al Hanif, “Pola Resistensi Bakteri dari Kultur Darah terhadap Golongan Penisilin di Laboratorium Mikrobiologi Klinik Fakultas Kedokteran Universitas Indonesia (LMK-FKUI) Tahun 2001-2006,” Jakarta: Universitas Indonesia, 2009.
A. A., Minyak Atsiri Tumbuhan Tropika Indonesia. Bandung: Penerbit ITB, 2000.
F. Febriana and A. V Amalia, “Potensi Kitchen Microbiology Untuk Meningkatkan Keterampilan Teknik Hands-On Dalam Pembelajaran Mikrobiologi,” Unnes Science Education Journal, vol. 5, no. 2, pp. 1210–1216, 2016.
Unduhan
Diterbitkan
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2024 Jurnal Indah Sains dan Klinis
Artikel ini berlisensiCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
This work is licensed under a 
